Courses with Gaps

Pain and Analgesics. Narcotic analgesics opioid system. Receptors, endogenous ligands, signal transduction pathways, role in pain. Concept of opioid-induced tolerance, physical dependence, addiction and pseudo-addiction. Basic pharmacology of narcotic analgesics (morphine, pethidine, methadone and congeners), narcotic antagonists, full and partial antagonists (nalorphine, levallorphan, naloxone). Non-Steroidal Anti-Inflammatory drugs (NSAIDs). Role of cyclo-oxygenase and prostaglandins in aetiology of inflammation, pain and fever, role of prostaglandins in homeostatic regulation of gastric function, kidney function, vasoconstriction and platelet activation. Basic pharmacology of NSAIDs (aspirin and salicylates, traditional NSAIDs, COX-2 inhibitors, acetaminophen). Rationale behind unique indication for low-dose aspirin as prophylactic treatment in development of CV disease. Pharmacokinetics of aspirin and the mechanism that lead to the development of salicylate toxicity. Mechanism underlying acetaminophen poisoning and its treatment. Epilepsy and Antiepileptic Drugs. Different types of seizures. Seizure types as determinants of specific antiepileptic drugs used in management. Spectrum of action of most commonly used drugs. Selection process of an epileptic drug for a given seizure type, based on its mechanism of action efficacy, clinical pharmacokinetics (ease of use), drug-drug interaction potential, tolerability (common side effects), serious toxicity (idiosyncratic reactions). Role of co-morbidities in the selection of an epileptic drug. Antidepressants Primary sites of action of the different classes of antidepressants, Tricyclic antidepressants, TCAs, (imipramine, amitriptyline, clomipramine, desipramine, doxepin). Selective-serotonin reuptake inhibitors, SSRIs, (citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline), Noradrenaline/serotonin reuptake inhibitors, SNRIs, (Venlafaxine, desvenlafaxine, nefazodone), monoamine oxidase inhibitors, MAOIs, (Irreversible, phenelzine, tranylcypromine and selegiline and reversible such as moclobemide). Adverse side effects of the different classes with respect to use in certain population (elderly, pregnancy), Pharmacological sites of actions that contribute to the acute or chronic side effects of these drugs. Proposed mechanism underlying the delayed therapeutic effects. Considerations in using irreversible MAOIs, their potential adverse effects and the important considerations in switching between MAOIs and SSRIs or other antidepressants. Antipsychotic drugs, the four well-defined dopamine systems in the brain as they relate to antipsychotic drug action and side effects. Distinction between the typical (chlorpromazine, haloperidol) and atypical antipsychotics (risperidone, olanzapine, quetiapine, ziprasidone, aripiprazole, paliperidone); difference in mechanism of action between the typical antipsychotics, atypical antipsychotics and the partial agonist, aripiprazole, common and rare side effects associated with use of both low potency and high potency antipsychotics as well as the second-generation antipsychotics. Sedative-Hypnotic Drugs used in treating anxiety and sleep disorders. Sleep and wakefulness. Structural aspects of GABAA receptor and the receptor. components (binding sites) mediating 232 the effects of drugs that modulate GABAA receptor activity. Differences between benzodiazepines with respect to time of onset, potency, metabolism and elimination half-lives. Similarities and differences between the benzodiazepines and the barbiturates in producing sedative-hypnotic effects. Factors to consider in choosing the most appropriate drug for specific clinical situations and/or individuals. Characteristics of benzodiazepines and other sedative-hypnotics that contribute to different degrees of abuse liability and withdrawal symptoms. Target sites or putative mechanisms of non-benzodiazepine drugs that can be used to treat sleep disorders, Barbiturates, bromides, cyclic ethers, paraldehyde, carbamic acid esters (meprobamate), chloral derivatives (chloral hydrate) piperazine dienes (glutethimide, methyprylon) alcohols. Target sites of action for SSRIs and strategy for using SSRIs in combination with benzodiazepines in the treatment of anxiety. Bipolar affective disorder and drugs used in management. Target sites of action for lithium, its pharmacokinetics, adverse effects and considerations in its use. Sites of action, adverse effects and considerations in using anticonvulsants (carbamazepine, lamotrigine, valproate) and the atypical antipsychotics (aripiprazole, olanzapine, quetiapine, risperidone, ziprasidone) to treat bipolar disorder. Potential risks of birth defects with use of lithium, valproate, carbamazepine and lamotrigine in pregnant women. Parkinson’s disease and drugs used in management. Pathophysiology of Parkinson’s disease and its presentation; functional circuitry of the nigrostriatal system. Major classes of drugs used in management and the timeline for their use, indications, mechanism of action, adverse effects and contraindications. Types and mechanisms of alternative treatments. Local Anaesthetics. Mechanism by which local anaesthetics block nerve conduction, how their physiochemical properties (esters and amides) influence their pharmacodynamics and pharmacokinetics. The side effects that may occur with their use and why they occur. Unique characteristics and the common clinical use for each prototypical local anaesthetic. Common uses with emphasis on spinal and epidural anaesthesia, commonly caused severe complications of their use. General anaesthetics. Definition of general anaesthesia and how it is achieved, stages of anaesthesia. Pharmacokinetics of inhalational anaesthetics. Blood, gas coefficient, ventilation rate and pulmonary blood flow influence on the onset (and termination) of action of inhalational anaesthetics, influence of tissue blood flow on the tension of anaesthetic gas in that tissue, definition of minimum alveolar concentration (MAC) and what information it provides on a volatile anaesthetic. Pharmacokinetic properties of the ultra-short-acting hypnotics and how they make this class of drugs popular general anaesthetic drugs. Advantages and disadvantages of clinically used inhaled and intravenously administered general anaesthetics, when they should be used, their contraindications. Concept that inhalational and intravenous anaesthetics cause varying degrees of respiratory depression with exception of ketamine. Use of anaesthetics in persons already taking drugs such as neuromuscular blocking drugs and CNS stimulants.

Drawing and detailing (by hand and using computer-aided-design skills) of civil engineering structures,for example building structures, highways, pipelines, bridges, dams, foundations, etc. utilizing standard symbols and conventions, dimensions, notes, titles, etc. Relationship to specifications. 300 Level

Ophthalmic lens manufacture; Lens surfacing, polishing and glazing techniques; Grinding of prismatic and cylindrical lenses. Edging, insertion of lenses into frames. Front bench spectacle works and verification; patient fitting; ophthalmic frames, facial measurement and selection based on frame sizes. Format making; marking and placement of optical centres; bifocals and multifocal segments. Spectacle adjustments and repairs. Manufacture of contact lenses and ocular prosthesis. Laboratory sessions are included.

Isolation and moisture control techniques. Patient and operator positions. Cross infection control. Illumination and magnification. Basic instrumentation. Diagnosis of common dental, pulpal and peri-apical conditions. Treatment of common dental, pulpal and peri-apical conditions.

Nursing Charts: Methods of taking/recording patient’s temperature, pulse, respiration: BP. Bed making: Prevention of bedsores: General skin care: Sterile dressing/bandaging, wound management, Nursing procedures in the management of surgical patients, Nursing procedures in ICU, management of ICU patients, Lifting techniques – lifting of patients: Intramuscular/Intravenous drug administration. Injection: Chemotherapy/Medication procedure on the wards, palliative care nursing: Nurse – Therapist relationship: Practical/Clinical Sessions.

Clinical pharmacology general aspect. Evaluation of drug therapy, clinical aspects of adverse drug reaction (inherent anomalies, acquired anomalies, treatment of adverse reactions). Basic mechanisms of drug-drug interactions. Consequences of drug-drug interactions. Clinically important drug interactions, beneficial embryonic and foetal clinical pharmacology, drug use in pregnancy, teratogenicity. Paediatric clinical pharmacology and therapeutics. Altered drug response in infants and response in infants and children, drug dosage in paediatrics. Geriatric clinical pharmacology and therapeutics. Altered drug response in the elderly drug dosage in geriatrics. 88

Patient assessment. Impression procedures. Bite registration. Aesthetic try-in appointments. Delivery and post-delivery care. Management of problems with different classes of dentures.

Introduction to cloud computing, cloud computing vendors, cloud computing threats, cloud reference model. Cloud-enabling technologies. Services, Service-Oriented Architectures. Cloud service models. Cloud deployment models. Introduction to data centres: servers, data storage, networking and virtualisation. Data centre networking. Introduction to server virtualisation software: VMware VSphere. Virtual machine management: configuration, placement and resource allocation. Power efficiency in virtual data centres. Fault tolerance in virtual data centres. The cloud cube model and security for cloud computing. Security in the cloud. Cloud threats, threat mitigation and security risks. Real world issues with cloud computing. Cloud security alliance. National Institute of Standards and Technology, Information Assurance Framework. Cloud audit. Cloud management audit/assurance programme, Cloud business continuity planning. Building a cloud. Architectural best practices: Designing for the cloud. Economics of the cloud. Cloud strategy. Cloud standards and the future. Security of the cloud.

Sound patterns in English Language (vowels and consonants, phonetics and phonology). English word classes (lexical and grammatical words, definitions, forms, functions, usages, collocations). Sentence in English (types: structural and functional, simple and complex). Grammar and Usage (tense, mood, modality and concord, aspects of language use in everyday life). Logical and Critical Thinking and Reasoning Methods (Logic and Syllogism, Inductive and Deductive Argument and Reasoning Methods, Analogy, Generalisation and Explanations). Ethical considerations, Copyright Rules and Infringements. Writing Activities: (Pre-writing , Writing, Post writing, Editing and Proofreading; Brainstorming, outlining, Paragraphing, Types of writing, Summary, Essays, Letter, Curriculum Vitae, Report writing, Note making and Mechanics of writing). Comprehension Strategies: (Reading and types of Reading, Comprehension Skills, 3RsQ). Information and Communication Technology in modern Language Learning. Language skills for effective communication. Major word formation processes. Writing and reading comprehension strategies. Logical and critical reasoning for meaningful presentations. Art of public speaking and listening. Report writing.

Sound patterns in English Language (vowels and consonants, phonetics and phonology). English word classes (lexical and grammatical words, definitions, forms, functions, usages, collocations). Sentence in English (types: structural and functional, simple and complex). Grammar and Usage (tense, mood, modality and concord, aspects of language use in everyday life). Logical and Critical Thinking and Reasoning Methods (Logic and Syllogism, Inductive and Deductive Argument and Reasoning Methods, Analogy, Generalisation and Explanations). Ethical considerations, Copyright Rules and Infringements. Writing Activities: (Pre-writing, Writing, Post-writing, Editing, and Proofreading; Brainstorming, outlining, Paragraphing, Types of writing, Summary, Essays, Letter, Curriculum Vitae, Report writing, Note making, etc. Mechanics of writing). Comprehension Strategies: (Reading and types of Reading, Comprehension Skills, 3RsQ). Information and Communication Technology in modern Language Learning. Language skills for effective communication. Major word-formation processes. Writing and reading comprehension strategies. Logical and critical reasoning for meaningful presentations. Art of public speaking and listening. Report writing.