Special Topics

At the end of this course, students should be able to: 1. outline endocrinology structure, function and molecular mechanism of action of steroid, thyroid and polypeptide hormones; 2. describe xenobiotics and forensic biochemistry detoxification mechanisms; 3. define metabolism of foreign compounds; 4. explain induction of microsomal enzymes and drug resistance; 5. identify medico-legal, blood, urine and sweat test; 6. describe recent development in forensic techniques; 7. discuss the biochemistry of ageing, nervous and muscle actions; 8. apply knowledge of basic research methodologies in biochemistry and molecular biology; 9. interpret the results of different diagnostic test in human diseases; 10. discuss porphyrins, haemoglobinopathies, hybridoma technology in medicine; 11. outline biochemistry of the viruses, spread, detection, drug treatment and others; 12. describe applications of immunotherapy assay of hormones; and 13. review current biochemical topics.

Endocrinology structure, function and molecular mechanism of action of steroid, thyroid and polypeptide hormones. Xenobiotics and forensic biochemistry. Detoxification mechanisms, metabolism of foreign compounds. Induction of microsomal enzymes and drug resistance. medico-legal, blood, urine and sweat test. Recent development in forensic techniques. Basic concept of aging, metabolic processes and aging, apoptosis, concept, pathways (intrinsic and extrinsic), role of oxidative stress in ageing, biochemical functions of nervous systems, neurotransmitters, biosynthesis and breakdown, diseases affecting the nervous tissues, muscles action. Biochemical and molecular concept, control. Metabolism of drugs and other foreign compounds. Cytochrome P450 and its isozymes microsomal enzymes in drugs metabolism and the toxicological consequences. The structure of biological membrane transport and diseases. Retroviruses, molecular basis and involvement in cancer. AIDS, biochemistry of the viruses, spread, detection, drug treatment and other. Cancer proto- oncogenes and oncogenes. Biochemical features of tropical disease. Gene rearrangement in Burkett’s lymphoma and other disease, genetic regulation of metabolism, the operon concept, induction and repression. Review of current biochemical topics.