Clinical Chemistry of Disease II

At the end of this course, students should be able to: 1. describe how to order clinically appropriate tests for disorders of the hypothalamo-pituitary axis; 2. illustrate how to conduct pregnancy test; 3. appreciate the ability to evaluate an infertile couple; 4. conduct hydrogen breath test; and 5. explain the role of tumour markers in screening, diagnosis.

Hypothalamo, Neuro and adreno hypophysis, functions, dysfunctions and investigations. Pituitary, thyroid functions, dysfunctions and investigations. Biochemical assessment of gonadal function in men and women. Investigations of fertility disorders. Biomarkers of 222 cardiovascular disease. Adrenocortical function, dysfunction and disorders. Biochemical changes in pregnancy. Diagnosis of pregnancy. Assessment of foetal and placental integrity. Role of chemical pathology in the diagnosis and management of cancer. Gastrointestinal functions, dysfunction and investigations, xylose absorption, pancreolauryl test, PABA test, faecal elastase, disaccharidases test, Schilling’s test, hydrogen breath test. The role of tumour markers in screening, diagnosis, treatment and monitoring of cancers.