GIT Pharmacology

At the end of this course, students should be able to: 1. describe pathophysiology of nausea and vomiting; 2. explain the basic and clinical pharmacology of the different classes of antiemetics, with specific examples; 3. list the common causes of constipation; 4. explain the basic pharmacology of drugs used to provide relief of constipation; 5. enumerate non-specific antidiarrhoeal drugs, lactulose; 6. describe pathophysiology of peptic ulcer disease; 7. list drugs that control gastric acid secretion and treat peptic ulcers; 8. list drugs to treat inflammatory bowel disease; and 9. enumerate anti-IBD therapies.

Drugs acting on the alimentary system, nausea and vomiting, pathophysiology, basic pharmacology of antiemetics, dopamine-receptor antagonists (metoclopramide, prochlorperazine, haloperidol). Antihistamines, serotonin antagonists, anticholinergics, benzodiazepines, corticosteroids. Constipation, common causes, basic pharmacology of drugs used for relief (bulk, osmotic and stimulant laxatives, saline and magnesium laxatives, detergent laxatives, non-absorbable sugars, polyethylene glycol, lubricants, enemas). Non- specific antidiarrhoeal drugs. Lactulose ulcer healing drugs. Drug management. H2-receptor antagonists. Antacids. Proton-pump inhibitors. Triple therapy. 219