Clinical Pharmacology and Therapeutics

At the end of this course, students should be able to: 1. define ADR, types, classes inherent and acquired anomalies; 2. describe the basic mechanisms and consequences of drug-drug interactions; 3. define the approaches to treatment of ADRs; 4. explain clinical importance of ADRs in relation to embryonic and foetal pharmacology; 5. enumerate drugs that cause teratogenic effects; 6. explain the concept of altered drug response in infants and children, and influence on paediatric drug dosing; and 7. discuss the concept of altered drug response in the elderly, and influence on geriatric drug dosing.

Clinical pharmacology general aspect. Evaluation of drug therapy, clinical aspects of adverse drug reaction (inherent anomalies, acquired anomalies, treatment of adverse reactions). Basic mechanisms of drug-drug interactions. Consequences of drug-drug interactions. Clinically important drug interactions, beneficial embryonic and foetal clinical pharmacology, drug use in pregnancy, teratogenicity. Paediatric clinical pharmacology and therapeutics. Altered drug response in infants and response in infants and children, drug dosage in paediatrics. Geriatric clinical pharmacology and therapeutics. Altered drug response in the elderly drug dosage in geriatrics. 88