Organic Pharmaceutical Chemistry

At the end of the course, students should be able to: 1. discuss the basic concepts in and fundamental principles of organic chemistry; 2. define, identify and name the functional group(s) present in an organic compound; 3. discuss the properties of acids and bases; 4. identify conjugate acid-base pairs; 5. use the Ka and pKa values to determine the strength of acid/base solutions; 6. discuss the properties of a buffer; 7. recognise and draw structural isomers and stereoisomers; 8. draw mirror image of any molecule; 9. identify the stereo centres in any molecule and assign the configuration as R and S; 10. recognise and explain how various physical properties might vary or might not vary for enantiomers or diasteroisomers; 11. explain that pure form of isomers can be obtained from a racemic mixture; 12. state the different methods/processes of resolution; and 13. be able to identify the problem of racemisation in drug discovery and the tools to predict it.

Fundamental concepts and techniques of organic chemistry. Functional group chemistry. Strengths of acids and bases. Introduction to stereochemistry of compounds. Molecular symmetry, racemisation and resolution methods.