Pharmacogenetics and Pharmacokinetics

At the end of the course, the students should be able to: 1. describe the concept of genetic variation (continuous and discontinuous) among the general population; 2. explain the significance of genetic polymorphism in the development, progression and treatment of human disease; 3. describe the models of drug distribution and elimination; 4. explain how dose, bioavailability, rate of absorption, apparent volume of distribution, total 5. clearance and elimination half-life affect the plasma concentrations of a drug after administration of a single dose; 6. describe the factors which determine the time-course of systemic accumulation of a drug 7. administered by infusion or multiple doses; 8. use the pharmacokinetic parameters to determine loading and maintenance doses of specific drug regimens; and 9. recognise the factors that affect hepatic and renal clearance (blood flow, protein binding, intrinsic clearance and many others).

Pattern of transmission of single gene trait. Hardy-Weinberg Law Conditions for its Validity, application. On concepts of continuous and discontinuous variation. Pharmacogenetics (drug metabolism, tissue metabolism and receptor alterations). Compartment models (one and two) kinetics after intravenous and oral dosing. Bioavailability, Drug distribution, Protein binding. Renal excretion of drugs. Urinary excretion data in Pharmacokinetic analysis.