Nucleic Acids Chemistry

At the end of this course, students should be able to: 1. describe genome organisation and biosynthesis of proteins; 2. explain metabolism of purines and pyrimidines, nucleosides and nucleotides; 3. identify abnormalities in nucleic acid metabolism-xeroderma pigmentation and skin cancer; 4. explain overview of nitrogen metabolism; 5. define biosynthesis of amino acids and identify molecules derived from amino acids and biosynthesis; 6. discuss degradation of nucleotides; and 7. apply biochemical knowledge in the clinics. 60

Genome organisation and biosynthesis of proteins. Metabolism of purines and pyrimidines, nucleosides and nucleotides. Abnormalities in nucleic acid metabolism-xeroderma pigmentation and skin cancer. Overview of nitrogen metabolism, biosynthesis of amino acids. Molecules derived from amino acids and biosynthesis and degradation of nucleotides.