General Pathology II

At the end of this course, students should be able to: 1. describe innate and adaptive immunity; 2. outline components of immune system; 3. define types of hypersensitivity disorders; 4. define the role of MHC in disease; 75 5. explain various mechanisms of tolerance and autoimmunity; 6. describe primary immunodeficiency; 7. discuss the pathology of HIV/AIDS and amyloidosis; 8. define oedema, embolism, thrombosis and shock; 9. explain pathophysiologic mechanisms and pathogenesis underlying oedema, embolism, thrombosis and shock; 10. enumerate morphologic and clinical features of oedema, embolism, thrombosis, shock; 11. define types of pathologic calcification; 12. explain fatty change and cellular accumulations of protein, glycogen and pigments; and 13. describe management of infectious diseases.

Immunopathology. Innate and adaptive immunity. Components of immune system (cells, tissues and molecules). Hypersensitivity disorders. Major histocompatibility complex. Mechanism of tolerance. Autoimmunity. Primary immunodeficiencies. AIDS. Amyloidosis. Haemodynamic disorders. Oedema. Embolism. Thrombosis. Shock. Neoplasia. Definition, benign/malignant tumours. Tumour nomenclature, aetiology of tumours. Genes involved in neoplastic process. Familial syndromes. Chemical, radiation and microbial carcinogenesis. Tumour immunity. Effect of tumour on host. Paraneoplastic syndromes. Intracellular accumulations. Pathologic calcification. Intracellular accumulations of protein. Lipids, glycogen and pigments. Infectious diseases. Malaria. Tuberculosis. Leprosy. Schistosomiasis. Syphilis. Amoebiasis. Typhoid. Onchocerciasis.