Chemotherapy of Neoplastic Diseases Anti-Neoplastic Agents

At the end of the course, the students should be able to: 1. explain the molecular basis of cancer; 2. state the principles of cancer chemotherapy; 3. classify and explain the mechanisms of action, pharmacokinetics and adverse effects (toxicities) of current drugs used in the treatment of cancers; 4. explain the rationale for the choice of a single and combination therapies in these disease states; and 5. discuss the mechanisms and issues of drug and multidrug resistance in cancer chemotherapy.

Introduction: Molecular basis of cancer including cell-cycle kinetics, principles of cancer chemotherapy and mechanisms underlying drug/multidrug resistance in cancer chemotherapy. Alkylating Agents, Antimetabolites, Hormones. Other anti-neoplastic agents (Antibiotics, Plant alkaloids and Miscellaneous). Radioactive isotopes; Control of antineoplastic chemotherapy; Summary of the chemotherapy of malignant diseases. Emerging new treatment with antibodies.