Chemotherapy of Microbial Diseases, Vaccines and Sera

At the end of the course, students should be able to: 1. state the definitions of the pharmacodynamic terms (bacteriostatic, bactericidal, time- dependence and many others) used to describe the effects of antimicrobial therapy; 2. classify and explain the mechanisms of action, pharmacokinetics, adverse drug reactions, contraindications of drugs used in the treatment of microbial and fungal diseases; 3. list the mechanisms by which pathogens acquire and express resistance to antibiotics; 4. classify and discuss the mechanisms of action, pharmacokinetics, adverse drug reactions, drug interaction, contraindications other therapeutic indications of antiretroviral drugs; and 5. explain the rationale for the choice of a single and combination therapies in these disease states.

Introduction: Terms and definitions of pharmacodynamic terms (bacteriostatic, bactericidal, time- dependent and many others) used to describe the effects of antimicrobial therapythe mechanisms by which pathogens acquire and express resistance to antibiotics. Antibacterials/Antibiotics: The pharmacology of the following drugs: Sulphonamides. Beta-lactam antibiotics (penicillins, cephalosporins, carbapenems, and monobactams). Tetracyclines. Chloramphenicol. Aminoglycosides. Miscellaneous antibiotics - macrolides, polymyxins, lincosamides, quinolones, metronidazole, bacitracin. Antifungal and antiviral agents. Drugs used in the treatment of Tuberculosis and Leprosy Antifungal agents. Antiviral agents; HIV/AIDS treatment. Vaccines design strategies and Sera.